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NIH Research Program Project (P01)

NHLBI Program Project Applications

Funds at least three interlocking projects on one heart, lung, blood or sleep question โ€” a programme, not a collection of separate grants.

Between cyclesNational Institutes of HealthUnited States

The National Heart, Lung, and Blood Institute funds program project grants for work across its whole remit โ€” the heart, the blood and lymphatic vessels, the lungs and blood itself, including transfusion medicine and blood resources, sleep disorders, and reaching into implementation science, health disparities and translational research.

The structural requirement is the whole point of the mechaniโ€ฆ

A programme of at least three interrelated research projects on one complex biomedical theme within NHLBI's remit โ€” the heart, blood and lymphatic vessels, lungs and blood, including transfusion medicine, blood resources, sleep disorders, implementation science, health disparities and translational research โ€” optionally supported by shared core units.

CycleiHow often this grant runs - e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.-
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.-
Award typeiThe form of funding - grant, equity, loan, tax credit, etc.Grant
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.-
Funding pooliThe total budget available across all awards in this round.-

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Guides for this application

All guides โ†’
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Between cycles

Nutrition Obesity Research Centers (NORCs)

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds shared research cores, pilot funding and a catalyst programme where a substantial nutrition or obesity research effort already exists.

$750K
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Closed

Optimizing Behavioral Sleep Interventions for Adolescents and Young Adults

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds a pilot trial of a behavioural sleep intervention for adolescents and young adults who have a mental health disorder or are at risk of one.

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Open

GREGoRi Data Coordination and Outreach Center

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds the one centre that coordinates a rare-disease genomics programme and gets its protocols, data and tools out to everybody else.

BiotechAI
$1.3MOct'26
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Open

GREGoRi Innovation Projects

NIH ยท United States

Funds a genuinely new experimental or computational approach to finding the cause of a rare genetic disorder, where the current state of the art falls short.

BiotechAI
$3 โ€“ $500KOct'26
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Open

GREGoRi Technology Integration Center

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds the centre that turns new molecular methods for rare-disease diagnosis into standards, best practices and a benchmarking dataset.

BiotechAI
$2.3MOct'26
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Open

Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds studies that watch patients rather than treat them, in bone, joint, rheumatic and skin disease. No intervention allowed.

Medtech
Nov'26