Research Projects to Enhance Applicability of Mammalian Models for Translational Research
Funds work proving that animal cancer models actually represent human biology well enough to base clinical decisions on. No clinical trial allowed.
Cancer research leans on mammalian models — mice, tumour transplants, tissue-derived systems — and the uncomfortable question underneath is how well any of them actually stand in for a human being. The National Cancer Institute funds work on exactly that question.
NCI draws a sharp line between this and the mechanistic research it usually funds. An ordinary R01 uses a model to test a hypothesis a…
Expanding, improving or transforming the usefulness of mammalian cancer and tumour models for translational research — demonstrating that models are robust representations of human biology, are fit to test clinically important questions, and give reliable information, plus validating and credentialling models and setting standards for how they are used.
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