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NIH Research Project Grant

National Cancer Institute's Investigator-Initiated Early Phase Clinical Trials for Cancer Treatment and Diagnosis

Funds a Phase 0, I or II cancer trial that the investigator designed, inside one of six named National Cancer Institute programme areas.

The National Cancer Institute runs large trial networks, and this is the opposite of that: money for a trial an individual investigator thought of and wants to run.

The phases in scope are 0, I and II — first-in-human, dose-finding and early signal-seeking. The interventions have to be cancer-targeted and either diagnostic or therapeutic.

What makes or breaks an application here is fit with a pr

Investigator-initiated Phase 0, I and II clinical trials of cancer-targeted diagnostic and therapeutic interventions, with at least one trial relevant to Cancer Therapy Evaluation, Cancer Imaging, Cancer Diagnosis, Radiation Research, Complementary and Alternative Medicine, or HIV and AIDS Malignancies research. Trials may stand alone or run alongside other aims.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.7 Jan 2027
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Grant
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.
Funding pooliThe total budget available across all awards in this round.$500K

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Last verified: 25 Aug 2026Funder reference: PAR-25-081Source: www.grants.gov