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NIH Research Project Grant

Pilot Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes

Funds a pilot trial of treatment or services for the phase after acute mental health care — holding gains, managing what is left, preventing relapse.

Mental health care concentrates on the acute episode. What happens afterwards — holding on to the improvement, living with what remains, not relapsing — is less studied and is where most of a person's life is lived.

This notice funds pilot trials of interventions for that post-acute phase, both therapeutic and service-delivery. The interventions have to be matched to the stage of illness in two w

Pilot effectiveness trials of therapeutic and service delivery interventions for post-acute management of mental health conditions, matched to stage of illness in focus and intensity, evaluating feasibility, tolerability, acceptability, safety and potential effectiveness, testing whether the intervention engages its presumed target or mechanism, and producing preliminary data for a larger effectiveness trial. A clinical trial is required.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.7 Jan 2028
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Grant
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.
Funding pooliThe total budget available across all awards in this round.

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Last verified: 25 Aug 2026Funder reference: PAR-25-206Source: www.grants.gov