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NIH Research Project Grant

Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes

Funds a fully powered trial of post-acute mental health treatment or services, testing not just whether it works but how and for whom.

The full-scale version of the National Institute of Mental Health's post-acute notice, and it asks a harder question than whether the intervention works.

The interventions are therapeutic and service-delivery approaches for the post-acute management of mental health conditions, and the populations named are youth, adults and older adults — the whole lifespan rather than one age band.

As in the p

Fully powered clinical trials evaluating the effectiveness of therapeutic and service delivery interventions for post-acute management of mental health conditions in youth, adults and older adults, matched to stage of illness in focus and intensity, and testing hypotheses about moderators, mediators and mechanisms of action. A clinical trial is required.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.7 Jan 2028
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Grant
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.
Funding pooliThe total budget available across all awards in this round.

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Last verified: 25 Aug 2026Funder reference: PAR-25-207Source: www.grants.gov