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NIH Exploratory/Developmental Research Grant

Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R21)

Funds the exploratory version of invasive human neural recording and stimulation work on mental health questions.

Some patients have electrodes inside their brain for clinical reasons — epilepsy monitoring, deep brain stimulation. While those electrodes are in place, they can record and stimulate with a precision no scan comes close to. This notice funds using that window.

What invasive recording offers is described plainly: an unparalleled view of the neural circuitry and dynamics underlying complex moods,

Invasive neural recording and stimulation studies in humans addressing mental health-relevant questions about neural circuitry and dynamics underlying moods, emotions, cognitive functions and behaviours at high spatial and temporal resolution, including causal tests by modulating network dynamics through the same electrodes, and development of new technologies and therapeutic approaches. Clinical trials are optional.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.7 Jan 2028
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Grant
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.
Funding pooliThe total budget available across all awards in this round.$200K

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Last verified: 25 Aug 2026Funder reference: PAR-25-291Source: www.grants.gov