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NIH Research Program Cooperative Agreement (U19)

National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U19)

Funds a coordinated multi-project program discovering and testing new drugs, ligands or neurostimulation devices for mental or substance use disorders.

OpenNational Institutes of HealthUnited States

Some drug and device discovery programs are too large for one investigator's project — they need several linked efforts, sharing resources and a common target, moving together. This notice is NIH's mechanism for exactly that scale of coordination.

This reissue of PAR-20-119 funds a research program of multiple projects, each contributing to discovery, preclinical development or proof-of-concept t…

A coordinated, multidisciplinary research programme of multiple linked projects sharing one major objective in discovery, preclinical development or proof-of-concept testing of candidate agents, neurostimulation approaches, ligands or circuit-engagement devices for mental disorders, substance use disorders or alcohol use disorder, with shared basic resources across projects. Clinical trials are optional.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.25 Oct 2027
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.—
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Cooperative agreement
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.—
Funding pooliThe total budget available across all awards in this round.—

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Last verified: 25 Aug 2026Funder reference: PAR-25-353Source: www.grants.gov