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NIH Research Program Cooperative Agreement (U19)

National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U19)

Funds a coordinated multi-project program discovering and testing new drugs, ligands or neurostimulation devices for mental or substance use disorders.

OpenNational Institutes of HealthUnited States

Some drug and device discovery programs are too large for one investigator's project โ€” they need several linked efforts, sharing resources and a common target, moving together. This notice is NIH's mechanism for exactly that scale of coordination.

This reissue of PAR-20-119 funds a research program of multiple projects, each contributing to discovery, preclinical development or proof-of-concept tโ€ฆ

A coordinated, multidisciplinary research programme of multiple linked projects sharing one major objective in discovery, preclinical development or proof-of-concept testing of candidate agents, neurostimulation approaches, ligands or circuit-engagement devices for mental disorders, substance use disorders or alcohol use disorder, with shared basic resources across projects. Clinical trials are optional.

CycleiHow often this grant runs - e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.25 Oct 2027
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.-
Award typeiThe form of funding - grant, equity, loan, tax credit, etc.Cooperative agreement
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.-
Funding pooliThe total budget available across all awards in this round.-

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Guides for this application

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Open

GREGoRi Data Coordination and Outreach Center

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds the one centre that coordinates a rare-disease genomics programme and gets its protocols, data and tools out to everybody else.

BiotechAI
$1.3MOct'26
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Open

GREGoRi Innovation Projects

NIH ยท United States

Funds a genuinely new experimental or computational approach to finding the cause of a rare genetic disorder, where the current state of the art falls short.

BiotechAI
$3 โ€“ $500KOct'26
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Open

GREGoRi Technology Integration Center

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds the centre that turns new molecular methods for rare-disease diagnosis into standards, best practices and a benchmarking dataset.

BiotechAI
$2.3MOct'26
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Open

Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds studies that watch patients rather than treat them, in bone, joint, rheumatic and skin disease. No intervention allowed.

Medtech
Nov'26
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Open

Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61)

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds early-stage clinical trials in arthritis, musculoskeletal and skin disease. A trial is compulsory.

MedtechBiotech
Nov'26
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Open

Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01)

NIH ยท United States

Funds theory and method development on how genetic and non-genetic factors together produce variation in complex traits, tested against large existing datasets.

BiotechAI
Nov'26