Expanding the Target Landscape by Drugging the Undruggable
Funds early-stage work to find a method or agent that hits a human disease target considered undruggable.
Most drug discovery targets proteins that are already known to be reachable — a pocket a small molecule can bind, a receptor with a known ligand. This notice funds the harder problem: targets nobody has found a way to drug yet.
The ask has two parts, and both are required. Identify a human-disease-relevant target class that counts as undruggable. Then develop a method or agent that is selective f…
Early-stage, exploratory identification of a human-disease-relevant undruggable target class and development of a method or agent selective for one or more targets within it, moving beyond established therapeutic types. A clinical trial is not allowed.
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