Precision Approaches in Radiation Synthetic Combinations (PAIRS)
Funds cancer therapies that combine radiation with a targeted drug, exploiting vulnerabilities radiation creates rather than ones already there.
Early synthetic-lethality cancer strategies mostly targeted mutations a tumour already had, fixed in its genome. This notice funds a different kind of target: vulnerabilities that only appear once radiation has acted on the tumour.
The premise is that radiation-induced, context-dependent tumour responses can be leveraged to create or sharpen a weakness that a molecularly targeted drug can then ex…
Cancer therapy strategies that exploit context-dependent, radiation-induced tumour vulnerabilities through drug-radiation combinations with molecularly targeted agents, submitted as either an exploratory/developmental project of up to two years or a research project of four to five years. Clinical trials are optional.
Sign up free to see the funding breakdown
Sign up free to see the industries in scope
Sign up free to see the full eligibility
Sign up free to see how to apply
Sign up free to see what you submit
Sign up free to see how they score you
Sign up free to see the timeline
Sign up free to see where teams trip up