Precision Approaches in Radiation Synthetic Combinations (PAIRS)
Funds cancer therapies that combine radiation with a targeted drug, exploiting vulnerabilities radiation creates rather than ones already there.
Early synthetic-lethality cancer strategies mostly targeted mutations a tumour already had, fixed in its genome. This notice funds a different kind of target: vulnerabilities that only appear once radiation has acted on the tumour.
The premise is that radiation-induced, context-dependent tumour responses can be leveraged to create or sharpen a weakness that a molecularly targeted drug can then ex…
Cancer therapy strategies that exploit context-dependent, radiation-induced tumour vulnerabilities through drug-radiation combinations with molecularly targeted agents, submitted as either an exploratory/developmental project of up to two years or a research project of four to five years. Clinical trials are optional.
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