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NIH Phase 1 Exploratory/Developmental Cooperative Agreement (UG3)

Clinical Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials

Funds the Clinical Coordinating Center that runs a multi-site heart, lung or blood trial, paired with a data-center twin.

A multi-site clinical trial needs someone running the clinical and operational side across every site at once. This notice funds that role — the Clinical Coordinating Center — for investigator-initiated multi-site trials relevant to NHLBI's mission.

The trials in scope are the same broad set NHLBI runs elsewhere: efficacy, comparative effectiveness, pragmatic, and dissemination and implementation

The Clinical Coordinating Center for multi-site investigator-initiated clinical trials relevant to NHLBI's mission — efficacy, comparative effectiveness, pragmatic, and dissemination and implementation science trials — run as a bi-phasic, milestone-driven cooperative agreement submitted jointly with a companion Data Coordinating Center application. A clinical trial is required.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.2 Nov 2028
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Cooperative agreement
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.
Funding pooliThe total budget available across all awards in this round.

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Last verified: 25 Aug 2026Funder reference: PAR-27-012Source: www.grants.gov