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NIH SBIR

Small Business Transition Grant for New Entrepreneurs (R43/R44)

Funds a first SBIR grant and hands-on entrepreneurial mentoring for a scientist who has never led independent research funding before.

ScheduledNational Institutes of HealthUnited States

Plenty of good scientists never start a company, and one reason is that the jump from academic funding to running a small business has no on-ramp. This notice is NIH and CDC's attempt at building one.

It funds Small Business Innovation Research Phase I applications, and Fast-Track applications combining Phase I and Phase II, for United States small business concerns. The research and development …

Small Business Innovation Research Phase I and Fast-Track grant applications for United States small business concerns, combining research and development funding with entrepreneurial training, mentoring and career development for a first-time principal investigator transitioning into entrepreneurship. A clinical trial is optional.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.5 Jan 2027
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.—
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Grant
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.—
Funding pooliThe total budget available across all awards in this round.—

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Last verified: 25 Aug 2026Funder reference: PAR-27-039Source: www.grants.gov