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NIH SBIR

SBIR/STTR Commercialization Readiness Pilot (CRP) Program

Funds late-stage R&D and technical work — trials, manufacturing scale-up, regulatory support — to finish a small business's NIH SBIR or STTR project.

OpenNational Institutes of HealthUnited States

A small business with a promising NIH SBIR or STTR result often hits a stretch of work that is too expensive and too unglamorous for the original award to cover — replicating a key finding, running the study a regulator will want to see, or scaling up manufacturing — and the usual follow-on grants are not built for that stretch.

The Commercialization Readiness Pilot exists for that gap. It pays f

Later-stage research, development and technical assistance beyond what a Phase II or Phase IIB SBIR/STTR award typically covers — independent replication of key studies, IND- or IDE-enabling studies, clinical studies, manufacturing scale-up and related quality work, and regulatory or other specialised technical support — for a small business concern finishing an NIH-funded SBIR or STTR project.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.5 Apr 2029
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Grant
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.
Funding pooliThe total budget available across all awards in this round.

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Last verified: 25 Aug 2026Funder reference: PAR-27-098Source: www.grants.gov