NIH Pragmatic Trials Conducted in Health Care Systems
Funds large pragmatic or implementation trials that test how well interventions work inside real health care settings.
A treatment that works in a research clinic does not always work in a busy emergency department or an under-resourced primary care practice. This notice funds finding out in the settings that actually matter to patients, clinicians and the people who pay for care.
Two kinds of trial are supported. Pragmatic trials that test whether an intervention is effective in routine clinical care. And implem…
Large-scale pragmatic trials testing intervention effectiveness in routine clinical care, and implementation trials testing strategies for delivering interventions within health care settings — spanning emergency departments, primary care, public health clinics, academic centers, federally qualified health centers, integrated networks and VA Medical Centers. Funded as a milestone-driven, phased cooperative agreement: a planning phase, then full trial execution.
Sign up free to see the funding breakdown
Sign up free to see the industries in scope
Sign up free to see the full eligibility
Sign up free to see how to apply
Sign up free to see what you submit
Sign up free to see how they score you
Sign up free to see the timeline
Sign up free to see where teams trip up
Guides for this application
All guides →NIH Biosketch Guide: Format, SciENcv Steps, and Examples
Learn what an NIH biosketch is, how the format works, what to prepare for SciENcv, and how startup teams should avoid common biosketch mistakes.
Write proposalHow to Write a Specific Aims Page
Learn how to write a specific aims page for NIH, SBIR-adjacent, and translational R&D grants, with structure, reviewer logic, examples, and common mistakes.
DocumentsGrant Work Plan Template: Work Packages, Gantt, Milestones, and Risks
Use this grant work plan template to structure work packages, tasks, owners, deliverables, Gantt timing, dependencies, and risk registers.
Submit & reportSAM.gov Registration and UEI Guide for Federal Grant Applicants
Learn how SAM.gov registration, UEI numbers, Grants.gov accounts, organization profiles, workspace roles, and renewal timing fit together.
More from NIH
All grants from this funder →GREGoRi Data Coordination and Outreach Center
🇺🇸NIH · United States
Funds the one centre that coordinates a rare-disease genomics programme and gets its protocols, data and tools out to everybody else.
GREGoRi Innovation Projects
NIH · United States
Funds a genuinely new experimental or computational approach to finding the cause of a rare genetic disorder, where the current state of the art falls short.
GREGoRi Technology Integration Center
🇺🇸NIH · United States
Funds the centre that turns new molecular methods for rare-disease diagnosis into standards, best practices and a benchmarking dataset.
Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases
🇺🇸NIH · United States
Funds studies that watch patients rather than treat them, in bone, joint, rheumatic and skin disease. No intervention allowed.
Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61)
🇺🇸NIH · United States
Funds early-stage clinical trials in arthritis, musculoskeletal and skin disease. A trial is compulsory.
Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01)
NIH · United States
Funds theory and method development on how genetic and non-genetic factors together produce variation in complex traits, tested against large existing datasets.
Similar grants
Browse the directory →
UNITED STATES MILITARY ACADEMY Broad Agency Announcement
AMC · United States
Funds extramural research for West Point's academic centers, across eight named campaigns from weapons science to quantum computing.
Strategic Research Agreement — Round 1
Breakthrough T1D · United States
Funds investigator-led type 1 diabetes research partnerships across preclinical discovery, treatment, and translational priorities.
DEVCOM ANALYSIS CENTER BROAD AGENCY ANNOUNCEMENT FOR APPLIED RESEARCH
AMC · United States
Funds applied research and prototype-stage work for the Army unit that turns data into modernization and readiness decisions.
ARMY APPLICATIONS LAB BROAD AGENCY ANNOUNCEMENT FOR DISRUPTIVE APPLICATIONS
AMC · United States
Funds research the Army Applications Lab is seeking for disruptive applications, though the notice itself names no specific topic.
DEVCOM ARMY RESEARCH LABORATORY BROAD AGENCY ANNOUNCEMENT FOR FOUNDATIONAL RESEARCH
AMC · United States
Funds basic and applied research across the Army Research Laboratory's whole science mission, with live topics posted on the lab's own separate site.
Assisting Specialty Crop Exports: Low Oxygen Storage and Packaging Systems for U.S. Tree Nuts with Phytosanitary Traceability
USDA · United States
Funds tech that verifies low-oxygen storage conditions so U.S. tree nut exports clear other countries' pest rules.