Illuminating AD/ADRD Genome to Enable Precision Genomic Medicine
Funds cross-ancestry, cross-species genomic studies of Alzheimer's disease and related dementias, aimed at therapeutic targets for precision medicine.
Alzheimer's disease and related dementias have genomic drivers that differ across populations and across related neurodegenerative diseases, and studying any one ancestry or one disease in isolation risks missing what is actually general versus what is specific.
This notice funds integrative, cross-disciplinary projects that scale up mechanistic study of those genomic drivers, using tools like ge…
Integrative, cross-disciplinary projects using genome editing, functional characterisation, single-cell and spatial omics, machine learning and comparative genomic analysis across genetic ancestries, model organisms or neurodegenerative diseases, in stem-cell, ex vivo and in vivo disease models, to identify the genomic drivers of Alzheimer's disease and related dementias and their actionable therapeutic targets.
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