Translational Transplantation Tolerance Cooperative Study Group
Funds a multi-center group translating transplant tolerance regimens toward the clinic, so grafts survive without lifelong immune-suppressing drugs.
Organ transplant recipients normally take immune-suppressing drugs for life, with all the infection and cancer risk that carries. This group exists to make that unnecessary, by getting tolerance regimens out of the lab and into people.
The goal is stated directly: facilitate clinical translation of safe and effective transplant tolerance regimens that achieve long-term graft survival without life…
Development, optimisation and evaluation of approaches to induce and maintain immune tolerance to allogeneic organ transplants, tested in translationally relevant models, aimed at clinical translation of tolerance regimens that sustain long-term graft survival without lifelong immunosuppressive drugs.
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