NIH Blueprint Initiative: Tools for Germline Gene Editing in the Nervous System
Funds developing and validating gene-editing tools in animal and other model systems used to study the human brain.
Some of the models neuroscience needs to study human brain disease do not exist yet, or exist only in animals whose genomes have not caught up with the questions researchers want to ask of them.
This funds developing, optimising, validating and applying germline and somatic transgenic and gene-editing approaches in experimental systems that model human brain anatomy, circuitry, cognition, behavio…
Developing, optimising, validating and applying germline and somatic transgenic and gene-editing approaches in experimental systems — including non-human-primate and other model systems combined with New Approach Methodologies — that model human brain anatomy, circuitry, cognition, behaviour and lifespan, justified against a specific neuroscience question rather than model convenience.
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