Elucidation and Validation of the role of Transporters in the Placenta, Lactating Mammary Gland, Developing Gut, and Blood Brain Barrier
Funds mapping how nutrients, drugs and chemicals cross the placenta, gut, mammary gland and blood-brain barrier in pregnancy and infancy.
A drug, a nutrient or an environmental chemical does not act on a fetus or a nursing infant the way it acts on an adult — it has to cross a barrier first, and each barrier behaves differently. This notice funds mapping how.
This is a second phase of the Transporter Elucidation Network (TEN), extending prior organ-focused models into a single, multi-barrier picture: maternal gut, placenta, lactati…
Mechanistic research establishing perinatal multi-barrier transporter frameworks — spanning maternal gut, placenta, lactating mammary epithelium, infant gut and infant blood-brain barrier — to build standards, resources, models and prototype multi-compartment approaches for studying transporter function, polarity, kinetics and transformation capacity in pregnancy, lactation and infancy.
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