National Institutes of Health logo
NIH Research Demonstration and Dissemination Project (R18)

BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS

Funds a novel recording or modulation technology for the human central nervous system from proof of concept up to readiness for first-in-human studies.

OpenNational Institutes of HealthUnited States

This is the notice that takes a neural interface as far as it can go before it enters a person.

The technologies are for recording from or modulating the human central nervous system, to treat or diagnose its diseases and disorders and to understand it better.

The range funded is stated exactly: from proof of concept up to the stage of readiness for first-in-human studies. That covers the work mโ€ฆ

Translation of novel recording and modulation technologies for the human central nervous system, using electrical, optical, magnetic, acoustic or combined signal modalities, from proof of concept up to readiness for first-in-human studies, for treating or diagnosing central nervous system diseases and disorders and for understanding the human central nervous system. Clinical trials are not allowed.

CycleiHow often this grant runs - e.g. annually, on a rolling basis, or a one-off call.Annual
Next deadlineiThe next date applications are due. Rolling means you can apply any time.28 Jan 2027
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.-
Award typeiThe form of funding - grant, equity, loan, tax credit, etc.Grant
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.-
Funding pooliThe total budget available across all awards in this round.-

Sign up free to see the funding breakdown

Sign up free to see the industries in scope

Sign up free to see the full eligibility

Sign up free to see how to apply

Sign up free to see what you submit

Sign up free to see how they score you

Sign up free to see the timeline

Sign up free to see where teams trip up

Guides for this application

All guides โ†’
National Institutes of Health logo
Open

Optimizing Behavioral Sleep Interventions for Adolescents and Young Adults

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds a pilot trial of a behavioural sleep intervention for adolescents and young adults who have a mental health disorder or are at risk of one.

Oct'26
National Institutes of Health logo
Open

GREGoRi Data Coordination and Outreach Center

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds the one centre that coordinates a rare-disease genomics programme and gets its protocols, data and tools out to everybody else.

BiotechAI
$1.3MOct'26
National Institutes of Health logo
Open

GREGoRi Innovation Projects

NIH ยท United States

Funds a genuinely new experimental or computational approach to finding the cause of a rare genetic disorder, where the current state of the art falls short.

BiotechAI
$3 โ€“ $500KOct'26
National Institutes of Health logo
Open

GREGoRi Technology Integration Center

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds the centre that turns new molecular methods for rare-disease diagnosis into standards, best practices and a benchmarking dataset.

BiotechAI
$2.3MOct'26
National Institutes of Health logo
Open

Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds studies that watch patients rather than treat them, in bone, joint, rheumatic and skin disease. No intervention allowed.

Medtech
Nov'26
National Institutes of Health logo
Open

Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61)

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds early-stage clinical trials in arthritis, musculoskeletal and skin disease. A trial is compulsory.

MedtechBiotech
Nov'26