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NIH Phase 1 Exploratory/Developmental Cooperative Agreement (UG3)

BRAIN Initiative: Next-Generation Devices for Recording and Modulation in the Human Central Nervous System

Funds taking a brain recording or stimulation device from prototype through safety testing and an FDA exemption into a first small clinical study.

OpenNational Institutes of HealthUnited States

This is the translational stretch of the BRAIN Initiative's device programme — the part between a device that works in a laboratory and a device that has been used in a person.

The funded activities are named: implementing clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation, obtaining an Investigational Device Exemption for a Significant Risk s…

Translational development of therapeutic and diagnostic devices for disorders of the nervous and neuromuscular systems — clinical prototype implementation, non-clinical safety and efficacy testing, design verification and validation, obtaining an Investigational Device Exemption for a Significant Risk study, and a subsequent small clinical study.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.28 Sept 2026
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.—
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Cooperative agreement
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.—
Funding pooliThe total budget available across all awards in this round.—

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Last verified: 25 Aug 2026Funder reference: RFA-NS-25-021Source: www.grants.gov