National Institutes of Health logo
NIH Phase 1 Exploratory/Developmental Grant (R61)

HEAL Initiative: Studies to Enable Analgesic Discovery

Funds the assays, screening and first characterisation that a pain drug discovery programme needs before it can start properly.

OpenNational Institutes of HealthUnited States

A drug discovery programme cannot begin until somebody has built the way of testing things. This notice funds that groundwork for pain.

It belongs to the government's pain and opioid initiative, and the goal behind the whole suite is safe, effective, non-addictive therapeutics to treat pain.

Three activities are in scope and they run in order. Developing assays to support a distinct testing funnโ€ฆ

Initial translational work supporting a pain drug discovery programme: development of assays to support a distinct testing funnel, screening efforts to identify hits, and initial characterisation of hits and potential therapeutic agents including small molecules, biologics and natural products, aimed at meeting the entry criteria of the Pain Therapeutics Development Program. Clinical trials are not allowed.

CycleiHow often this grant runs - e.g. annually, on a rolling basis, or a one-off call.Annual
Next deadlineiThe next date applications are due. Rolling means you can apply any time.15 Jan 2027
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.-
Award typeiThe form of funding - grant, equity, loan, tax credit, etc.Grant
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.-
Funding pooliThe total budget available across all awards in this round.-

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Guides for this application

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Between cycles

Nutrition Obesity Research Centers (NORCs)

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds shared research cores, pilot funding and a catalyst programme where a substantial nutrition or obesity research effort already exists.

$750K
National Institutes of Health logo
Open

Optimizing Behavioral Sleep Interventions for Adolescents and Young Adults

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds a pilot trial of a behavioural sleep intervention for adolescents and young adults who have a mental health disorder or are at risk of one.

Oct'26
National Institutes of Health logo
Open

GREGoRi Data Coordination and Outreach Center

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds the one centre that coordinates a rare-disease genomics programme and gets its protocols, data and tools out to everybody else.

BiotechAI
$1.3MOct'26
National Institutes of Health logo
Open

GREGoRi Innovation Projects

NIH ยท United States

Funds a genuinely new experimental or computational approach to finding the cause of a rare genetic disorder, where the current state of the art falls short.

BiotechAI
$3 โ€“ $500KOct'26
National Institutes of Health logo
Open

GREGoRi Technology Integration Center

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds the centre that turns new molecular methods for rare-disease diagnosis into standards, best practices and a benchmarking dataset.

BiotechAI
$2.3MOct'26
National Institutes of Health logo
Open

Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds studies that watch patients rather than treat them, in bone, joint, rheumatic and skin disease. No intervention allowed.

Medtech
Nov'26
FDA Office of Orphan Products Development logo
Open

Efficient and Innovative Natural History Studies Addressing Unmet Needs in Rare Diseases

๐Ÿ‡บ๐Ÿ‡ธFDA OOPD ยท United States

Funds natural-history studies that improve preparedness for rare disease trial pathways.

BiotechMedtech
$600KFeb'28
US Department of Health and Human Services logo
Open

Pregnancy and Postpartum Hypertension Control Initiative (OWH) โ€” Seed

๐Ÿ‡บ๐Ÿ‡ธHHS ยท United States

Supports maternal health and blood pressure monitoring initiatives for underserved pregnant and postpartum populations through community-linked innovation.

MedtechBiotech
$300K โ€“ $550K
National Center for Advancing Translational Sciences logo
Open

NCATS Preclinical Proof of Concept Studies for Rare Diseases

๐Ÿ‡บ๐Ÿ‡ธNCATS ยท United States

Funds U.S. researchers and companies conducting preclinical efficacy studies to advance therapeutic candidates for rare diseases toward IND applications.

BiotechMedtech+1
$275KJun'27
US Department of Health and Human Services logo
Open

Making America Healthy Again โ€” Dementia Disparities (OMH) โ€” Seed

๐Ÿ‡บ๐Ÿ‡ธHHS ยท United States

Supports community-based teams reducing dementia and brain-health disparities in underserved groups through social-determinant-focused strategies.

MedtechNeurotech+1
$450K โ€“ $600K
National Center for Advancing Translational Sciences logo
Open

NCATS Clinical Trial Readiness for Rare Diseases

๐Ÿ‡บ๐Ÿ‡ธNCATS ยท United States

Funds U.S. researchers and companies generating natural history data, biomarkers, and outcome measures needed to design clinical trials for rare diseases.

BiotechMedtech+1
$275KFeb'27
National Institute for Occupational Safety and Health logo
Open

NIOSH WTC Health Program โ€” R21 Exploratory Grant

๐Ÿ‡บ๐Ÿ‡ธNIOSH ยท United States

Funds exploratory clinical studies improving diagnostics and treatments from disaster-related conditions.

BiotechMedtech
$365KDec'26