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NIH Research Project Grant

INCLUDE Project: Transformative Research Awards for Down syndrome

Funds bold, unconventional Down syndrome research that could open an entirely new scientific or clinical direction.

The INCLUDE Project is NIH's cross-institute effort to improve health and quality of life for people with Down syndrome, covering the condition itself and everything that co-occurs with it. This notice is the big-swing award in the INCLUDE family: a Transformative Research Award for work that could change what the field considers possible.

What is asked for is groundbreaking, exceptionally innova

Transformative Research Award applications proposing groundbreaking, exceptionally innovative, original or unconventional research on any topic relevant to Down syndrome or its co-occurring conditions, with the potential to create new scientific paradigms, clinical approaches or technologies. No preliminary data are required. A clinical trial is not allowed under this R01 mechanism.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.15 Jun 2028
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Grant
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.
Funding pooliThe total budget available across all awards in this round.$3M

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Last verified: 25 Aug 2026Funder reference: RFA-OD-27-004Source: www.grants.gov