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NIH Exploratory/Developmental Cooperative Agreement Phase II (UH3)

Assay Validation of High Quality Markers for Clinical Studies in Cancer (UH3)

Funds the clinical validation of a cancer biomarker assay whose analytical performance has already been proven.

OpenNational Institutes of HealthUnited States

A cancer biomarker only becomes useful when someone shows the assay behaves the same way in real patient specimens, in more than one laboratory, on more than one occasion. The National Cancer Institute funds that step here, and only that step.

The markers in scope are molecular, cellular or imaging, and the uses named are detection, diagnosis, prognosis, monitoring, prediction of response or resi…

Clinical validation, over up to three years, of analytically validated molecular, cellular or imaging assays for cancer detection, diagnosis, prognosis, monitoring, response prediction, prevention and control, including pharmacodynamic and toxicity markers, and cross-laboratory harmonisation, using specimens from retrospective or prospective studies.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.14 Oct 2026
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.—
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Cooperative agreement
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.—
Funding pooliThe total budget available across all awards in this round.—

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Last verified: 25 Aug 2026Funder reference: PAR-25-075Source: www.grants.gov