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NIH Research Project Cooperative Agreement (U01)

National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U01)

Funds one investigator's discovery-to-proof-of-concept project on a new drug, ligand or neurostimulation device for a mental or substance use disorder.

OpenNational Institutes of HealthUnited States

New treatments for mental illness, substance use disorder and alcohol use disorder can come from a molecule or from a way of engaging the brain's own circuits directly — and getting either from an idea to a testable candidate takes more than a single experiment.

This reissue of PAR-20-118 funds discovery, preclinical development and proof-of-concept testing of new, rationally based candidate agen…

A single investigator's discrete, circumscribed project on discovery, preclinical development or proof-of-concept testing of new candidate agents and neurostimulation approaches for mental disorders, substance use disorders or alcohol use disorder, including development of novel ligands or circuit-engagement devices to characterise or validate drug and device targets. Clinical trials are optional.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.25 Oct 2027
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.—
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Cooperative agreement
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.—
Funding pooliThe total budget available across all awards in this round.—

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Last verified: 25 Aug 2026Funder reference: PAR-25-352Source: www.grants.gov