National Institutes of Health logo
NIH Research Project Cooperative Agreement (U01)

National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U01)

Funds one investigator's discovery-to-proof-of-concept project on a new drug, ligand or neurostimulation device for a mental or substance use disorder.

OpenNational Institutes of HealthUnited States

New treatments for mental illness, substance use disorder and alcohol use disorder can come from a molecule or from a way of engaging the brain's own circuits directly โ€” and getting either from an idea to a testable candidate takes more than a single experiment.

This reissue of PAR-20-118 funds discovery, preclinical development and proof-of-concept testing of new, rationally based candidate agenโ€ฆ

A single investigator's discrete, circumscribed project on discovery, preclinical development or proof-of-concept testing of new candidate agents and neurostimulation approaches for mental disorders, substance use disorders or alcohol use disorder, including development of novel ligands or circuit-engagement devices to characterise or validate drug and device targets. Clinical trials are optional.

CycleiHow often this grant runs - e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.25 Oct 2027
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.-
Award typeiThe form of funding - grant, equity, loan, tax credit, etc.Cooperative agreement
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.-
Funding pooliThe total budget available across all awards in this round.-

Sign up free to see the funding breakdown

Sign up free to see the industries in scope

Sign up free to see the full eligibility

Sign up free to see how to apply

Sign up free to see what you submit

Sign up free to see how they score you

Sign up free to see the timeline

Sign up free to see where teams trip up

Guides for this application

All guides โ†’
National Institutes of Health logo
Between cycles

Nutrition Obesity Research Centers (NORCs)

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds shared research cores, pilot funding and a catalyst programme where a substantial nutrition or obesity research effort already exists.

$750K
National Institutes of Health logo
Open

Optimizing Behavioral Sleep Interventions for Adolescents and Young Adults

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds a pilot trial of a behavioural sleep intervention for adolescents and young adults who have a mental health disorder or are at risk of one.

Oct'26
National Institutes of Health logo
Open

GREGoRi Data Coordination and Outreach Center

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds the one centre that coordinates a rare-disease genomics programme and gets its protocols, data and tools out to everybody else.

BiotechAI
$1.3MOct'26
National Institutes of Health logo
Open

GREGoRi Innovation Projects

NIH ยท United States

Funds a genuinely new experimental or computational approach to finding the cause of a rare genetic disorder, where the current state of the art falls short.

BiotechAI
$3 โ€“ $500KOct'26
National Institutes of Health logo
Open

GREGoRi Technology Integration Center

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds the centre that turns new molecular methods for rare-disease diagnosis into standards, best practices and a benchmarking dataset.

BiotechAI
$2.3MOct'26
National Institutes of Health logo
Open

Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds studies that watch patients rather than treat them, in bone, joint, rheumatic and skin disease. No intervention allowed.

Medtech
Nov'26