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NIH Phase 1 Exploratory/Developmental Cooperative Agreement (UG3)

Clinical Trials and Ancillary Studies Conducted within NIH-Funded Clinical Trial Research Networks

Funds a multi-center clinical trial or ancillary study run inside an already-funded NIH Clinical Trial Research Network, in two milestone-driven phases.

Running a multi-center clinical trial usually means building sites, coordination and data systems from nothing. This notice skips that step: it pays for trials that run inside a Clinical Trial Research Network NIH already funds, so the infrastructure exists before the science does.

The National Institute of Neurological Disorders and Stroke leads this notice alongside other participating institut

Multi-center clinical trials and ancillary studies conducted within an established, NIH-funded Clinical Trial Research Network, structured as a bi-phasic UG3 planning and start-up phase of up to two years with a possible transition to a UH3 implementation phase of up to five more years, under the cooperative oversight of the administering institute. A clinical trial is required.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.10 Nov 2026
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Cooperative agreement
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.
Funding pooliThe total budget available across all awards in this round.

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Last verified: 25 Aug 2026Funder reference: PAR-27-007Source: www.grants.gov