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NIH STTR

Small Business Transition Grant for New Entrepreneurs (R41/R42)

Funds a first STTR grant and entrepreneurial mentoring for a scientist who partners with a nonprofit institution and has never led research funding before.

ScheduledNational Institutes of HealthUnited States

This is the STTR twin of NIH's small-business transition grant, and it differs from its SBIR sibling in two concrete ways: it requires a formal research partnership with a nonprofit institution, and it runs through NIH alone rather than NIH and the CDC together.

It funds Small Business Technology Transfer Phase I applications, and Fast-Track applications combining Phase I and Phase II, for United…

Small Business Technology Transfer Phase I and Fast-Track grant applications for United States small business concerns partnering with a nonprofit research institution, combining research and development funding with entrepreneurial training, mentoring and career development for a first-time principal investigator transitioning into entrepreneurship. A clinical trial is optional.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.5 Jan 2027
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.—
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Grant
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.—
Funding pooliThe total budget available across all awards in this round.—

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Last verified: 25 Aug 2026Funder reference: PAR-27-040Source: www.grants.gov