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Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development

Funds small-molecule drug candidates from a lab bench through Phase I testing, with NIH's own chemistry and toxicology experts on call.

An academic lab can often find a promising small molecule, but rarely has the pharmacology, toxicology and manufacturing muscle to get it into a person safely — and that gap is where a lot of good candidates quietly die.

This notice funds crossing it. Small-molecule drug discovery and development work runs in the investigator's own laboratory, with access to NIH-supported subject matter experts a

Phased cooperative-agreement support for small-molecule drug discovery and development toward clinical testing, run in the investigator's own laboratory with NIH-supported subject matter experts and contract research organizations providing medicinal chemistry, pharmacokinetics, toxicology, formulation and GMP synthesis capacity through Phase I. Biologics are excluded.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.16 Jun 2027
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Cooperative agreement
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.
Funding pooliThe total budget available across all awards in this round.

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Last verified: 25 Aug 2026Funder reference: PAR-28-043Source: www.grants.gov