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NIH Research Project Cooperative Agreement (U01)

Alzheimer's Drug-Development Program

Funds early drug candidates for Alzheimer's disease, from lab bench through the first human safety trial.

ScheduledNational Institutes of HealthUnited States

The riskiest, most expensive stretch of drug development sits between finding something promising and watching it survive a first human test, and that stretch is exactly where good Alzheimer's candidates run out of money. This notice funds crossing it.

What it funds is preclinical and early-stage clinical, Phase I, development of novel small-molecule and biologic drug candidates aimed at preventi…

Preclinical through early-stage, Phase I, clinical development of novel small-molecule and biologic drug candidates to prevent, slow the progression of, or treat the cognitive and behavioral symptoms of Alzheimer's disease, run in the investigator's own laboratory or through contract research organizations specializing in preclinical drug development.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.One-off
Next deadlineiThe next date applications are due. Rolling means you can apply any time.18 Jun 2027
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.—
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Cooperative agreement
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.—
Funding pooliThe total budget available across all awards in this round.—

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Last verified: 25 Aug 2026Funder reference: RFA-AG-28-009Source: www.grants.gov