Cooperative Program for Modeling Clinical Transplantation
Funds lab models that stand in for animal testing in solid organ transplant research.
A transplant therapy that works in an animal often fails to translate to a person, and the nonhuman primate studies that predict best are slow, expensive and hard to scale. This notice funds better stand-ins.
What it funds is new approach methods, refined mouse models, or both together, for modeling the local and systemic immune response in solid organ transplantation, built to be clinically tran…
Development of new approach methods and refined mouse models — including immune-competent microphysiological systems, organoids, ex-vivo perfused human organs, precision-cut tissue slices, and computational systems biology models — that overcome known translation obstacles, reduce reliance on nonhuman primates, and demonstrate relevance to clinical outcomes in solid organ transplantation.
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