Collaborative Network for Clinical Research on Immune Tolerance
Funds one network running clinical trials and mechanism studies on training the immune system into tolerance for transplants and autoimmune disease.
The immune system can be trained to stop attacking something — a transplanted organ, the body's own tissue, an allergen — and this network exists to make that training reliable enough to use in the clinic.
Three scientific goals are named. Clinical trials testing whether promising tolerogenic strategies are safe and effective in liver, kidney and pancreatic islet transplantation, in allergic dise…
Clinical trials testing tolerogenic strategies for safety and efficacy in liver, kidney and pancreatic islet transplantation, allergic disease and asthma, and autoimmune disease; basic mechanism research on immune tolerance conducted alongside those trials; and development, refinement and validation of immune assays to monitor the induction, maintenance and loss of tolerance.
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