Restoring Joint Health and Function to Reduce Pain (RE-JOIN) 2.0
Funds mapping how joint tissue is wired by pain-sensing nerves, expanding a running NIH consortium.
Most treatments for joint pain target inflammation or damage in the joint itself, not the nerves that turn that damage into pain. This notice is the second phase of an NIH consortium — RE-JOIN — built to understand that wiring in detail.
The plan is to map how sensory neurons reach every tissue that makes up a joint: bone, cartilage, synovium, the joint capsule, ligament, tendon, fascia and muscl…
Mapping how sensory neurons innervate joint tissue — bone, cartilage, synovium, joint capsule, ligament, tendon, fascia, muscle and peri-articular tissue — across a wider range of joints, patients and disease conditions than the first phase of the RE-JOIN consortium covered. Includes clinical pain phenotyping, preclinical and non-animal disease models, preclinical testing of joint-targeted candidates already identified, and joint atlases integrating imaging with molecular data.
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