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NIH Research Enhancement Awards (R15)

HEAL Initiative: Pain Research Enhancement Program (PREP)

Funds basic and mechanistic pain research at institutions that receive little NIH funding, with students working on the project alongside the investigator.

OpenNational Institutes of HealthUnited States

Most NIH money goes to a small number of research-intensive universities. This programme exists for the institutions that fall outside that group, and it does three named things at once.

First, it supports rigorous basic or mechanistic pain research led by principal investigators at those institutions. The science has to stand on its own.

Second, it builds partnerships. The notice wants integratโ€ฆ

Rigorous basic and mechanistic pain research at institutions eligible for NIH's Academic Research Enhancement Award, building interdisciplinary partnerships with investigators at other U.S. institutions and actively engaging health professional trainees, undergraduate and graduate students in the research. Clinical trials are optional.

CycleiHow often this grant runs - e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.23 Nov 2026
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.-
Award typeiThe form of funding - grant, equity, loan, tax credit, etc.Grant
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.-
Funding pooliThe total budget available across all awards in this round.-

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Between cycles

Nutrition Obesity Research Centers (NORCs)

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds shared research cores, pilot funding and a catalyst programme where a substantial nutrition or obesity research effort already exists.

$750K
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Open

Optimizing Behavioral Sleep Interventions for Adolescents and Young Adults

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds a pilot trial of a behavioural sleep intervention for adolescents and young adults who have a mental health disorder or are at risk of one.

Oct'26
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Open

GREGoRi Data Coordination and Outreach Center

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds the one centre that coordinates a rare-disease genomics programme and gets its protocols, data and tools out to everybody else.

BiotechAI
$1.3MOct'26
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Open

GREGoRi Innovation Projects

NIH ยท United States

Funds a genuinely new experimental or computational approach to finding the cause of a rare genetic disorder, where the current state of the art falls short.

BiotechAI
$3 โ€“ $500KOct'26
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Open

GREGoRi Technology Integration Center

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds the centre that turns new molecular methods for rare-disease diagnosis into standards, best practices and a benchmarking dataset.

BiotechAI
$2.3MOct'26
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Open

Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds studies that watch patients rather than treat them, in bone, joint, rheumatic and skin disease. No intervention allowed.

Medtech
Nov'26