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NIH Research Project Cooperative Agreement (U01)

Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access

Funds research using data from expanded access to investigational drugs for people with ALS who are not eligible for any ongoing trial.

OpenNational Institutes of HealthUnited States

People with amyotrophic lateral sclerosis who do not meet the entry criteria for any running trial can sometimes still receive an investigational drug, through the expanded access route in federal drug law. Until now, almost nothing has been learned from them. This notice changes that.

The legal basis is named directly: expanded access for investigational drugs or biological products as set out i…

Scientific research using data from expanded access to investigational drugs or biological products under section 561 of the Federal Food, Drug, and Cosmetic Act, targeting intermediate-size populations of people with amyotrophic lateral sclerosis who are not eligible for ongoing clinical trials, covering prevention, diagnosis, mitigation, treatment or cure. A clinical trial is required.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.One-off
Next deadlineiThe next date applications are due. Rolling means you can apply any time.10 Nov 2026
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.—
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Cooperative agreement
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.—
Funding pooliThe total budget available across all awards in this round.$40M

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Last verified: 25 Aug 2026Funder reference: RFA-NS-26-001Source: www.grants.gov