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NIH Phase 1 Exploratory/Developmental Grant (R61)

NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders

Funds Phase I trials for heart, lung, blood and sleep disorders — and pays for the final preclinical work needed to start one.

The National Heart, Lung, and Blood Institute funds investigator-initiated Phase I clinical trials of diagnostics and therapeutics for heart, lung, blood and sleep disorders, in adults and children.

What makes this route unusual is what it pays for besides the trial. The award covers final-stage preclinical activities needed to make the trial possible — stability studies, shipping studies, site t

Investigator-initiated Phase I clinical trials of diagnostic and therapeutic interventions for heart, lung, blood and sleep disorders in adults and children, together with the final-stage preclinical activities directly required to start the trial. Two-phase, milestone-driven.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.7 Jan 2027
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Grant
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.
Funding pooliThe total budget available across all awards in this round.

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Last verified: 25 Aug 2026Funder reference: PAR-25-026Source: www.grants.gov