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NIH Research Project Grant

Pilot Hybrid Effectiveness-Implementation Trials for Mental Health Interventions

Funds a pilot effectiveness study of a mental health intervention — and requires it to test whether the intervention engages its presumed mechanism.

This is the rung below the institute's definitive effectiveness trials, and it exists because those trials require pilot data that has to come from somewhere.

Two kinds of work are encouraged. Optimising the effectiveness of preventive and therapeutic interventions that already have demonstrated efficacy, for use with broader populations or in community practice settings. And developing and preli

Pilot effectiveness studies optimising preventive and therapeutic mental health interventions with demonstrated efficacy for broader populations or community practice settings, and developing and preliminarily testing innovative services interventions, explicitly addressing whether the intervention engages the target or mechanism presumed to underlie its effects. A clinical trial is required.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.15 Oct 2027
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Grant
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.
Funding pooliThe total budget available across all awards in this round.

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Last verified: 25 Aug 2026Funder reference: PAR-25-178Source: www.grants.gov