Expanding the Therapeutic Pipeline for Treating and Preventing Alzheimer's Disease and Related Dementias: Preclinical Validation and Drug Discovery for Novel Candidate Targets
Funds rigorous preclinical validation and early drug discovery against novel Alzheimer's and related-dementia targets, before human trials.
Most Alzheimer's drugs fail because the target they were built against did not hold up. This notice funds rigorously testing a target before committing years to a drug built around it.
Two connected activities are in scope: validating novel drug targets for Alzheimer's disease and Alzheimer's-related dementias, and early-stage discovery of the drugs meant to hit them — small molecules, biologics,…
Preclinical validation of novel drug targets for Alzheimer's disease and related dementias, and early-stage drug discovery of small molecules, biologics and emerging therapeutic modalities against those targets, using the U01 cooperative agreement mechanism.
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