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NIH Research Project Cooperative Agreement (U01)

NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement

Funds prospective observational studies or biomarker-validation studies that need new data or biospecimen collection, through a cooperative agreement.

OpenNational Institutes of HealthUnited States

Some questions in medicine can only be answered by watching forward in time — collecting data or biospecimens as they happen, rather than looking back at what already exists. This is a standing route to fund exactly that kind of work.

Two study types qualify: investigator-initiated observational studies, or biomarker validation studies. Both must need prospective collection of data or biospecimen…

Investigator-initiated observational studies or biomarker validation studies requiring prospective collection or continued analysis of data or biospecimens, with no disease, condition or health domain named. A clinical trial is not allowed.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.5 Jul 2029
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.—
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Cooperative agreement
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.—
Funding pooliThe total budget available across all awards in this round.—

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Last verified: 25 Aug 2026Funder reference: PAR-27-058Source: www.grants.gov