Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R01)
Funds work on how GLP-1 and related drugs change cancer risk — raising it for some cancers, lowering it for others.
Incretin mimetics — GLP-1 agonists, GIP-1 agents, and dual GLP-1/GIP-1 drugs — are now taken by very large numbers of people, and the evidence so far suggests they may raise the risk of some obesity-related cancers while lowering the risk of others. Nobody knows why.
This notice funds preclinical and patient-based studies of the mechanisms behind that. NIH is explicit about a second goal alongsid…
Preclinical and patient-based studies of the mechanisms by which incretin mimetics — GLP-1 agonists or antagonists, GIP-1 agents, and dual GLP-1/GIP-1 agents — affect cancer risk, rather than shorter-term outcomes such as weight loss and diabetes.
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