Early surgical intervention compared to standard care in neonates with symptoms of necrotising enterocolitis (NEC)
Funds a UK trial testing early surgery against standard monitoring for neonates with NEC.
Peer reviewers and the funding committee explicitly weigh value for money, expecting the depth of an applicant's justification to scale with how much funding is being requested. The outline application has to include a mandatory one-page flow diagram illustrating the study design and participant flow, and a mandatory one-page reference list, on top of a research plan capped at five A4 pages that r…
The HTA Programme wants a single trial testing whether operating as soon as possible beats active monitoring for acutely unwell, very preterm babies with suspected necrotising enterocolitis but no bowel perforation. Applicants must justify their own comparator, sample size and outcome measures, with neurodevelopment at 24 months and intestinal autonomy at 12 months named as priority endpoints. Recruitment from historically underserved, high-disease-burden populations is explicitly encouraged.
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