Grants of $250K to $1M
Explore grants with an award between $250,000 and $1 million. This directory lists funding for product development, applied research, feasibility and early commercialization, the range where most national innovation programs and second-phase awards sit, with the deadline and eligibility on every listing.
Showing 73-96 of 731 grants
NIEHS SBIR Phase I
🇺🇸NIEHS · United States
Supports United States. small businesses building environmental health technologies at feasibility stage.
NIH SBIR Phase I
🇺🇸NIH SEED · United States
Funds early stage United States biomedical teams through NIH seed support for feasibility work on prototype ready ideas.
Computational Approaches to Curation at Scale for Biomedical Research Assets
🇺🇸NIH · United States
Funds computational methods that curate biomedical data at scale, so datasets and models become usable faster than hand-curation allows.
NCATS Preclinical Proof of Concept Studies for Rare Diseases
🇺🇸NCATS · United States
Funds U.S. researchers and companies conducting preclinical efficacy studies to advance therapeutic candidates for rare diseases toward IND applications.
NIDCD Research Grants for Translating Basic Research into Clinical Practice
NIH · United States
Funds translational research turning basic findings into clinical tools for communication disorders, with practical clinical impact required.
Early-Stage Development of Informatics Technologies for Cancer Research and Management
NIH · United States
Funds early-stage development of new cancer-research software tools, from first prototype to their first real users.
Limited Competition: Clinical and Translational Science Award (CTSA) Program: Collaborative and Innovative Acceleration Award
🇺🇸NIH · United States
Funds collaborative projects that build, test and spread new tools or methods across NIH's national network of clinical and translational research hubs.
Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Development and Validation of Model Systems to Facilitate Neurotherapeutic Discovery
NIH · United States
Funds building animal and tissue models that behave enough like a real neurological disease to test drugs against.
Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Assay Development and Neurotherapeutic Agent Identification
NIH · United States
Funds building the assays and running the screens that find drug candidates for neurological disease — the on-ramp to NIH's Blueprint network.
Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools
🇺🇸NIH · United States
Funds a small mechanistic or minimal-risk clinical trial at a degree-granting school that gets under $6 million a year from NIH.
Chemical Countermeasures Research Program (CCRP) Initiative: Basic Research on The Deleterious Effects of Acute Exposure to Ultra-Potent Synthetic (UPS) Opioids
🇺🇸NIH · United States
Funds basic research on the harm caused by a single exposure to ultra-potent synthetic opioids, including the effects that appear later.
ARO Early Career Program (YIP)
🇺🇸ARO · United States
Supports early-career faculty pursuing Army basic research through direct funding pathways.
Catalyze: Enabling Technologies and Transformative Platforms for HLBS Research
🇺🇸NIH · United States
Funds rigorously validating a transformative, multi-use platform or technology aimed at heart, lung, blood or sleep disease.
NIDCR Behavioral and Social Intervention Clinical Trial Planning and Implementation Cooperative Agreement
🇺🇸NIH · United States
Funds up to two years planning a behavioural or social intervention trial in oral health, then up to five running it if the milestones are met.
Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions
🇺🇸NIH · United States
Funds a small research project at a college that teaches undergraduates and receives little NIH money, with students doing the research.
Academic-Industrial Partnerships for Translation of Technologies for Diagnosis and Treatment
NIH · United States
Funds academic-industry partnerships that turn a lab discovery into a working diagnostic or treatment tool, without a clinical trial attached.
Integration of Imaging and Fluid-Based Tumor Monitoring in Cancer Therapy
🇺🇸NIH · United States
Funds work combining imaging with liquid biopsy during cancer treatment, to see sooner whether it is working or resistance is emerging.
Mechanisms that Impact Cancer Risk after Bariatric Surgery (R01)
🇺🇸NIH · United States
Funds mechanistic work on how bariatric surgery changes a person's cancer risk — not on weight loss or diabetes.
Molecular Imaging of Inflammation in Cancer
🇺🇸NIH · United States
Funds molecular imaging that shows how inflammation and cancer interact inside a living body, rather than in a dish or a slide.
Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools
🇺🇸NIH · United States
Funds small research projects at health-profession and graduate schools that have received little NIH support, with students doing the work.
Commercial Fishing Occupational Safety Research Cooperative Agreement
🇺🇸CDC · United States
Funds research and engineering work that cuts injuries and deaths in commercial fishing, from vessel design to severe-weather detection.
Efficient and Innovative Natural History Studies Addressing Unmet Needs in Rare Diseases
🇺🇸FDA OOPD · United States
Funds natural-history studies that improve preparedness for rare disease trial pathways.
Reissue of RFA-FD-22-001 - Efficient and Innovative Natural History Studies Addressing Unmet Needs in Rare Diseases
FDA · United States
Funds natural history studies that track how a rare disease unfolds over time, to close data gaps blocking new treatments for it.
Reissue of RFA-FD-23-001- Clinical Studies of Orphan Products Addressing Unmet Needs of Rare Diseases
FDA · United States
Funds clinical trials testing whether a product works and is safe for a rare disease, aimed at a new indication or a labeling change.